Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation
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چکیده
منابع مشابه
GDF 15 ( growth differentiation factor 15 )
The premature GDF/PDF/MIC-1 protein consists of 308 amino acids that contain a 29 amino acid signal peptide, a 167 amino acid propeptide, and a 112 amino acid mature protein. The mature protein is secreted as a homodimer linked by disulfide bonds and is released from the propeptide following intracellular cleavage at RXXR furine-like cleavage site. The mature peptide of GDF-1/MIC-1 contains two...
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The Mad family proteins are transcriptional repressors belonging to the basic region/helix-loop-helix/leucine zipper family. They share a common obligatory dimerization partner, Max, with the oncoprotein c-Myc and antagonize the function of Myc to activate transcription. The Myc/Max/Mad network has therefore been suggested to function as a molecular switch that regulates cell growth and differe...
متن کاملThe murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.
In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of iron into the blood stream from duodenal enterocytes and macrophages. It has been suggested that hepcidin suppression is controlled by growth differentiation factor 15 (GDF15), a member of the transforming growth factor-β superfamily of c...
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BACKGROUND The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force ac...
متن کاملGrowth differentiation factor 15: a canary in a coal mine?
It has been 50 years since Dr. William B. Kannel coined the term “factors of risk” in relation to cardiovascular disease (1). Since then, clinical risk assessment, including the use of circulating biomarkers, has become an integral part of medical practice. The current era of genomics, proteomics, and metabolomics is projected to lead to the discovery of an immense number of novel candidate bio...
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ژورنال
عنوان ژورنال: iScience
سال: 2021
ISSN: 2589-0042
DOI: 10.1016/j.isci.2021.102554